Laboratório de Integração dos Sistemas Biológicos
Laboratory of Biological Systems Integration
Linha de pesquisa: Sinais biológicos da regulação bioenergética e controle de qualidade celular em doenças degenerativas
Research interests: Systems biology and drug discovery
Resumo: Controle de qualidade mitocondrial e seu impacto nos ajustes celulares fisiológicos e patológicos. A meta a curto/médio prazo é rastrear alvos e desenvolver moléculas capazes de modular o controle de qualidade mitocondrial, afetando diretamente a eficiência energética celular. No longo prazo o grupo visa transferir esse conhecimento para a sociedade na forma de novas terapias contra doenças degenerativas. Atualmente, o grupo desenvolve três moléculas que afetam o controle de qualidade mitocondrial com potencial uso no tratamento de doenças cardiovasculares.
Abstract: Dr. Julio Ferreira leads a multi-disciplinary group that spans basic to translational research. His lab research focuses in understanding the role of mitochondria in integrating intracellular signals that affect function, morphology and life/death decision of somatic cells. Ferreira’s lab uses different molecular, biochemical and physiological approaches todiscover new mitochondrial-related targets that affect cell biology. These studies will help develop more powerful and selective molecules to treat diseases. His lab recently designed selective peptides that interfere with proteinprotein interactions to study signal transduction in normal and disease states (i.e. cardiac diseases). More recently, research in his lab focuses on the validation of small molecule activators of aldehyde dehydrogenases, a family of detoxifying enzymes that are involved in a variety of human diseases. His group recently found that aldehydes strongly affects progenitor cell fate decisions.
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